side effects to b12 injections Injection Safety, & Risks side effects of a b12

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The subcutaneous route is used at much smaller doses than oral because a 100 mg injection would require two 50 mg vials and about 6 mL of liquid when each vial is mixed with 3.0 mL BAC water, which is too much for one subcutaneous site

Some patients also experience mild diarrhea, swelling, or itching